2025 Big 12 Conference Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 11/08/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Texas Tech | 8 | 9 | 47 | 56 | 7.00 |
| 2 | Kansas State | 7 | 9 | 36 | 45 | 6.43 |
| 3 | Arizona | 7 | 7 | 31 | 38 | 5.43 |
| 3 | TCU | 8 | 11 | 27 | 38 | 4.75 |
| 5 | Arizona State | 7 | 5 | 32 | 37 | 5.29 |
| 5 | Houston | 8 | 5 | 32 | 37 | 4.63 |
| 7 | Kansas | 8 | 2 | 34 | 36 | 4.50 |
| 8 | BYU | 7 | 10 | 24 | 34 | 4.86 |
| 8 | Iowa State | 8 | 6 | 28 | 34 | 4.25 |
| 10 | Utah | 7 | 5 | 28 | 33 | 4.71 |
| 10 | West Virginia | 8 | 7 | 26 | 33 | 4.13 |
| 10 | Baylor | 8 | 4 | 29 | 33 | 4.13 |
| 13 | Cincinnati | 7 | 2 | 30 | 32 | 4.57 |
| 14 | Colorado | 8 | 4 | 24 | 28 | 3.50 |
| 15 | UCF | 7 | 6 | 21 | 27 | 3.86 |
| 16 | Oklahoma State | 7 | 2 | 21 | 23 | 3.29 |