2025 Big 12 Conference Leaders Passes Defended - Games in October Only through 11/08/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Texas Tech | 4 | 2 | 26 | 28 | 7.00 |
| 2 | BYU | 4 | 7 | 16 | 23 | 5.75 |
| 3 | Kansas State | 3 | 5 | 16 | 21 | 7.00 |
| 3 | TCU | 4 | 6 | 15 | 21 | 5.25 |
| 3 | Houston | 4 | 1 | 20 | 21 | 5.25 |
| 6 | Cincinnati | 4 | 1 | 19 | 20 | 5.00 |
| 7 | Oklahoma State | 4 | 2 | 17 | 19 | 4.75 |
| 8 | Arizona | 3 | 3 | 13 | 16 | 5.33 |
| 9 | Kansas | 3 | 1 | 14 | 15 | 5.00 |
| 10 | Utah | 3 | 1 | 13 | 14 | 4.67 |
| 11 | West Virginia | 3 | 3 | 10 | 13 | 4.33 |
| 12 | Arizona State | 3 | 1 | 11 | 12 | 4.00 |
| 13 | Colorado | 3 | 1 | 10 | 11 | 3.67 |
| 14 | UCF | 3 | 0 | 10 | 10 | 3.33 |
| 14 | Iowa State | 3 | 0 | 10 | 10 | 3.33 |
| 16 | Baylor | 3 | 1 | 7 | 8 | 2.67 |