2025 Big 12 Conference Leaders Passes Defended - Games vs. FBS Teams With Non-Winning Record Only through 11/08/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Texas Tech | 5 | 5 | 27 | 32 | 6.40 |
| 2 | Arizona | 4 | 4 | 20 | 24 | 6.00 |
| 3 | Houston | 6 | 6 | 17 | 23 | 3.83 |
| 4 | Baylor | 4 | 3 | 19 | 22 | 5.50 |
| 5 | Kansas State | 2 | 4 | 14 | 18 | 9.00 |
| 6 | Kansas | 4 | 1 | 16 | 17 | 4.25 |
| 7 | West Virginia | 3 | 2 | 14 | 16 | 5.33 |
| 8 | UCF | 4 | 3 | 11 | 14 | 3.50 |
| 9 | TCU | 4 | 4 | 9 | 13 | 3.25 |
| 9 | Utah | 4 | 3 | 10 | 13 | 3.25 |
| 9 | Cincinnati | 4 | 1 | 12 | 13 | 3.25 |
| 12 | Colorado | 2 | 2 | 10 | 12 | 6.00 |
| 12 | Arizona State | 2 | 0 | 12 | 12 | 6.00 |
| 14 | Iowa State | 3 | 1 | 10 | 11 | 3.67 |
| 15 | BYU | 3 | 5 | 5 | 10 | 3.33 |
| 16 | Oklahoma State | 2 | 0 | 4 | 4 | 2.00 |