2025 Conference USA Leaders Rushing Defense - Games vs. FBS non-Power 5 Conference Teams Only through 11/22/2025
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 8 | 247 | 1171 | 4.74 | 7 | 30.88 | 146.38 |
| 2 | New Mexico State | 9 | 344 | 1519 | 4.42 | 9 | 38.22 | 168.78 |
| 3 | Missouri State | 8 | 264 | 1063 | 4.03 | 10 | 33.00 | 132.88 |
| 4 | Middle Tennessee State | 9 | 335 | 1331 | 3.97 | 11 | 37.22 | 147.89 |
| 4 | Kennesaw State | 8 | 292 | 1258 | 4.31 | 11 | 36.50 | 157.25 |
| 4 | UTEP | 9 | 363 | 1516 | 4.18 | 11 | 40.33 | 168.44 |
| 7 | Western Kentucky | 9 | 308 | 1604 | 5.21 | 12 | 34.22 | 178.22 |
| 8 | FIU | 9 | 307 | 1405 | 4.58 | 13 | 34.11 | 156.11 |
| 9 | Jacksonville State | 9 | 330 | 1456 | 4.41 | 17 | 36.67 | 161.78 |
| 10 | Delaware | 8 | 268 | 1353 | 5.05 | 19 | 33.50 | 169.13 |
| 10 | Liberty | 10 | 379 | 1753 | 4.63 | 19 | 37.90 | 175.30 |
| 12 | Sam Houston State | 9 | 340 | 1736 | 5.11 | 23 | 37.78 | 192.89 |