2025 Conference USA Leaders Rushing Defense - Games vs. Non-Conference Teams Only through 10/08/2025
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | New Mexico State | 3 | 110 | 341 | 3.10 | 1 | 36.67 | 113.67 |
| 1 | Louisiana Tech | 3 | 113 | 376 | 3.33 | 1 | 37.67 | 125.33 |
| 3 | Western Kentucky | 3 | 118 | 667 | 5.65 | 3 | 39.33 | 222.33 |
| 4 | FIU | 4 | 125 | 599 | 4.79 | 5 | 31.25 | 149.75 |
| 4 | Liberty | 4 | 155 | 787 | 5.08 | 5 | 38.75 | 196.75 |
| 6 | Kennesaw State | 4 | 152 | 614 | 4.04 | 6 | 38.00 | 153.50 |
| 6 | Jacksonville State | 4 | 164 | 644 | 3.93 | 6 | 41.00 | 161.00 |
| 6 | Delaware | 3 | 112 | 505 | 4.51 | 6 | 37.33 | 168.33 |
| 6 | Sam Houston State | 3 | 108 | 542 | 5.02 | 6 | 36.00 | 180.67 |
| 10 | UTEP | 4 | 171 | 679 | 3.97 | 7 | 42.75 | 169.75 |
| 10 | Middle Tennessee State | 4 | 162 | 693 | 4.28 | 7 | 40.50 | 173.25 |
| 12 | Missouri State | 4 | 122 | 662 | 5.43 | 12 | 30.50 | 165.50 |