2025 Conference USA Leaders Rushing Defense - Games in August/September Only through 10/08/2025
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 5 | 159 | 528 | 3.32 | 1 | 31.80 | 105.60 |
| 2 | FIU | 4 | 123 | 589 | 4.79 | 4 | 30.75 | 147.25 |
| 2 | New Mexico State | 4 | 175 | 694 | 3.97 | 4 | 43.75 | 173.50 |
| 4 | Western Kentucky | 5 | 183 | 1054 | 5.76 | 6 | 36.60 | 210.80 |
| 5 | Delaware | 4 | 146 | 665 | 4.55 | 7 | 36.50 | 166.25 |
| 5 | Jacksonville State | 5 | 201 | 843 | 4.19 | 7 | 40.20 | 168.60 |
| 5 | Middle Tennessee State | 5 | 193 | 850 | 4.40 | 7 | 38.60 | 170.00 |
| 8 | Kennesaw State | 5 | 189 | 769 | 4.07 | 8 | 37.80 | 153.80 |
| 8 | UTEP | 5 | 213 | 774 | 3.63 | 8 | 42.60 | 154.80 |
| 8 | Sam Houston State | 4 | 143 | 647 | 4.52 | 8 | 35.75 | 161.75 |
| 11 | Liberty | 5 | 205 | 1125 | 5.49 | 9 | 41.00 | 225.00 |
| 12 | Missouri State | 5 | 151 | 821 | 5.44 | 14 | 30.20 | 164.20 |