2021 Conference USA Leaders Rushing Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Southern Mississippi | 4 | 126 | 353 | 2.80 | 3 | 31.50 | 88.25 |
| 2 | UTSA | 5 | 172 | 508 | 2.95 | 4 | 34.40 | 101.60 |
| 2 | Florida International | 4 | 157 | 646 | 4.11 | 4 | 39.25 | 161.50 |
| 4 | North Texas | 5 | 195 | 993 | 5.09 | 6 | 39.00 | 198.60 |
| 5 | Louisiana Tech | 4 | 115 | 518 | 4.50 | 7 | 28.75 | 129.50 |
| 5 | Old Dominion | 5 | 225 | 800 | 3.56 | 7 | 45.00 | 160.00 |
| 5 | Charlotte | 4 | 184 | 1135 | 6.17 | 7 | 46.00 | 283.75 |
| 8 | UTEP | 5 | 167 | 634 | 3.80 | 8 | 33.40 | 126.80 |
| 8 | UAB | 5 | 155 | 736 | 4.75 | 8 | 31.00 | 147.20 |
| 10 | Middle Tennessee | 5 | 179 | 841 | 4.70 | 9 | 35.80 | 168.20 |
| 10 | Florida Atlantic | 4 | 175 | 1014 | 5.79 | 9 | 43.75 | 253.50 |
| 12 | Marshall | 5 | 249 | 1077 | 4.33 | 10 | 49.80 | 215.40 |
| 13 | Western Kentucky | 5 | 226 | 1127 | 4.99 | 14 | 45.20 | 225.40 |
| 14 | Rice | 4 | 154 | 910 | 5.91 | 16 | 38.50 | 227.50 |