2021 Conference USA Leaders Sacks - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | UTSA | 12 | 33.0 | 254 | 2.75 |
| 2 | North Texas | 11 | 33.0 | 230 | 3.00 |
| 3 | Marshall | 12 | 37.0 | 228 | 3.08 |
| 4 | UAB | 11 | 32.0 | 210 | 2.91 |
| 5 | Middle Tennessee | 11 | 28.0 | 198 | 2.55 |
| 6 | Western Kentucky | 11 | 32.0 | 193 | 2.91 |
| 7 | Rice | 9 | 23.0 | 171 | 2.56 |
| 8 | UTEP | 12 | 23.0 | 158 | 1.92 |
| 9 | Old Dominion | 11 | 20.0 | 135 | 1.82 |
| 10 | Southern Mississippi | 10 | 19.0 | 131 | 1.90 |
| 11 | Florida Atlantic | 10 | 16.0 | 125 | 1.60 |
| 12 | Louisiana Tech | 9 | 13.0 | 92 | 1.44 |
| 13 | Charlotte | 9 | 12.0 | 88 | 1.33 |
| 14 | Florida International | 10 | 13.0 | 66 | 1.30 |