2021 Conference USA Leaders Sacks - Games in October Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | UTSA | 4 | 16.0 | 121 | 4.00 |
| 2 | Middle Tennessee | 4 | 15.0 | 100 | 3.75 |
| 3 | Western Kentucky | 5 | 15.0 | 91 | 3.00 |
| 3 | UTEP | 4 | 13.0 | 91 | 3.25 |
| 5 | UAB | 4 | 17.0 | 87 | 4.25 |
| 6 | North Texas | 4 | 11.0 | 78 | 2.75 |
| 7 | Rice | 4 | 9.0 | 67 | 2.25 |
| 8 | Marshall | 4 | 10.0 | 58 | 2.50 |
| 9 | Florida Atlantic | 4 | 8.0 | 51 | 2.00 |
| 10 | Charlotte | 4 | 6.0 | 41 | 1.50 |
| 11 | Old Dominion | 4 | 5.0 | 35 | 1.25 |
| 12 | Louisiana Tech | 4 | 3.0 | 24 | 0.75 |
| 13 | Southern Mississippi | 4 | 4.0 | 23 | 1.00 |
| 14 | Florida International | 4 | 5.0 | 20 | 1.25 |