2021 Conference USA Leaders Sacks - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Western Kentucky | 6 | 24.0 | 159 | 4.00 |
| 2 | Middle Tennessee State | 7 | 19.0 | 152 | 2.71 |
| 3 | UTSA | 7 | 19.0 | 149 | 2.71 |
| 4 | UAB | 6 | 21.0 | 133 | 3.50 |
| 5 | UTEP | 8 | 18.0 | 128 | 2.25 |
| 6 | Marshall | 6 | 23.0 | 116 | 3.83 |
| 6 | Southern Miss | 6 | 15.0 | 116 | 2.50 |
| 8 | Charlotte | 7 | 12.0 | 93 | 1.71 |
| 9 | Rice | 5 | 13.0 | 92 | 2.60 |
| 10 | North Texas | 5 | 13.0 | 90 | 2.60 |
| 11 | Old Dominion | 5 | 11.0 | 69 | 2.20 |
| 12 | Florida Atlantic | 5 | 9.0 | 57 | 1.80 |
| 13 | Louisiana Tech | 5 | 8.0 | 49 | 1.60 |
| 14 | FIU | 6 | 8.0 | 34 | 1.33 |