2021 Conference USA Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Louisiana Tech | 2 | 4.0 | 32 | 2.00 |
| 2 | Western Kentucky | 2 | 3.0 | 25 | 1.50 |
| 3 | Charlotte | 2 | 3.0 | 24 | 1.50 |
| 4 | Rice | 2 | 2.0 | 13 | 1.00 |
| 4 | Middle Tennessee | 1 | 1.0 | 13 | 1.00 |
| 6 | Old Dominion | 1 | 2.0 | 11 | 2.00 |
| 6 | Southern Mississippi | 1 | 2.0 | 11 | 2.00 |
| 8 | North Texas | 1 | 1.0 | 7 | 1.00 |