2021 Conference USA Leaders Sacks - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Marshall | 5 | 20.0 | 112 | 4.00 |
| 2 | North Texas | 5 | 15.0 | 103 | 3.00 |
| 3 | Southern Mississippi | 4 | 11.0 | 82 | 2.75 |
| 4 | Old Dominion | 5 | 9.0 | 68 | 1.80 |
| 5 | Western Kentucky | 5 | 9.0 | 65 | 1.80 |
| 6 | Middle Tennessee | 5 | 10.0 | 62 | 2.00 |
| 7 | UTEP | 5 | 9.0 | 60 | 1.80 |
| 8 | Rice | 4 | 7.0 | 55 | 1.75 |
| 9 | UTSA | 5 | 9.0 | 54 | 1.80 |
| 10 | Louisiana Tech | 4 | 7.0 | 51 | 1.75 |
| 11 | Charlotte | 4 | 7.0 | 49 | 1.75 |
| 12 | Florida International | 4 | 7.0 | 36 | 1.75 |
| 13 | Florida Atlantic | 4 | 3.0 | 26 | 0.75 |
| 14 | UAB | 5 | 2.0 | 6 | 0.40 |