2025 Conference USA Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 11/22/2025
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Delaware | 2 | 5.0 | 30 | 2.50 |
| 2 | Missouri State | 2 | 3.0 | 28 | 1.50 |
| 3 | Louisiana Tech | 2 | 3.0 | 27 | 1.50 |
| 4 | Western Kentucky | 1 | 2.0 | 18 | 2.00 |
| 5 | Jacksonville State | 1 | 2.0 | 17 | 2.00 |
| 6 | FIU | 1 | 2.0 | 11 | 2.00 |
| 7 | Kennesaw State | 2 | 4.0 | 9 | 2.00 |
| 7 | Sam Houston State | 2 | 3.0 | 9 | 1.50 |