2025 American Conference Leaders Passes Defended - Games vs. FBS non-Power 5 Conference Teams Only through 11/01/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Memphis | 7 | 8 | 32 | 40 | 5.71 |
| 2 | UTSA | 6 | 5 | 28 | 33 | 5.50 |
| 3 | Rice | 7 | 3 | 21 | 24 | 3.43 |
| 4 | USF | 5 | 6 | 20 | 26 | 5.20 |
| 5 | Navy | 7 | 4 | 19 | 23 | 3.29 |
| 6 | Temple | 6 | 5 | 18 | 23 | 3.83 |
| 6 | North Texas | 7 | 5 | 18 | 23 | 3.29 |
| 8 | Tulsa | 6 | 4 | 16 | 20 | 3.33 |
| 8 | East Carolina | 5 | 3 | 16 | 19 | 3.80 |
| 10 | Tulane | 5 | 1 | 15 | 16 | 3.20 |
| 11 | UAB | 6 | 2 | 14 | 16 | 2.67 |
| 12 | Army | 6 | 5 | 13 | 18 | 3.00 |
| 13 | Florida Atlantic | 6 | 0 | 12 | 12 | 2.00 |
| 14 | Charlotte | 6 | 3 | 8 | 11 | 1.83 |