2025 American Conference Leaders Passes Defended - Games in August/September Only through 11/01/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Tulane | 5 | 6 | 23 | 29 | 5.80 |
| 2 | Memphis | 5 | 6 | 21 | 27 | 5.40 |
| 3 | Rice | 5 | 2 | 20 | 22 | 4.40 |
| 4 | UTSA | 4 | 3 | 17 | 20 | 5.00 |
| 5 | Temple | 4 | 3 | 16 | 19 | 4.75 |
| 5 | East Carolina | 5 | 3 | 16 | 19 | 3.80 |
| 5 | Florida Atlantic | 4 | 0 | 16 | 16 | 4.00 |
| 8 | Tulsa | 5 | 3 | 15 | 18 | 3.60 |
| 8 | Army | 4 | 2 | 15 | 17 | 4.25 |
| 10 | UAB | 4 | 1 | 13 | 14 | 3.50 |
| 11 | USF | 4 | 4 | 11 | 15 | 3.75 |
| 11 | Navy | 4 | 3 | 11 | 14 | 3.50 |
| 13 | North Texas | 5 | 6 | 9 | 15 | 3.00 |
| 14 | Charlotte | 4 | 0 | 7 | 7 | 1.75 |