2025 American Conference Leaders Passes Defended - Games vs. FBS non-Power 5 Conference Teams Only through 12/20/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | USF | 10 | 10 | 35 | 45 | 4.50 |
| 1 | Tulane | 10 | 10 | 31 | 41 | 4.10 |
| 3 | North Texas | 11 | 9 | 28 | 37 | 3.36 |
| 4 | Memphis | 10 | 8 | 39 | 47 | 4.70 |
| 4 | East Carolina | 9 | 8 | 27 | 35 | 3.89 |
| 6 | UTSA | 10 | 7 | 35 | 42 | 4.20 |
| 6 | Army | 10 | 7 | 22 | 29 | 2.90 |
| 8 | Navy | 11 | 6 | 25 | 31 | 2.82 |
| 8 | Tulsa | 9 | 6 | 20 | 26 | 2.89 |
| 8 | Charlotte | 9 | 6 | 18 | 24 | 2.67 |
| 11 | Temple | 9 | 5 | 24 | 29 | 3.22 |
| 12 | Rice | 10 | 3 | 30 | 33 | 3.30 |
| 12 | Florida Atlantic | 10 | 3 | 28 | 31 | 3.10 |
| 12 | UAB | 10 | 3 | 21 | 24 | 2.40 |