2025 Atlantic Coast Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 10/24/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Louisville | 3 | 231 | 679 | 177 | 910 | 5.14 | 303.3 |
| 2 | Miami (FL) | 3 | 331 | 581 | 203 | 912 | 4.49 | 304.0 |
| 3 | Pittsburgh | 5 | 500 | 1169 | 356 | 1669 | 4.69 | 333.8 |
| 4 | Clemson | 6 | 690 | 1372 | 409 | 2062 | 5.04 | 343.7 |
| 5 | Wake Forest | 4 | 654 | 735 | 304 | 1389 | 4.57 | 347.3 |
| 6 | California | 6 | 1028 | 1201 | 395 | 2229 | 5.64 | 371.5 |
| 7 | Florida State | 5 | 682 | 1206 | 353 | 1888 | 5.35 | 377.6 |
| 8 | Virginia Tech | 6 | 838 | 1432 | 384 | 2270 | 5.91 | 378.3 |
| 9 | Duke | 5 | 591 | 1339 | 329 | 1930 | 5.87 | 386.0 |
| 10 | Georgia Tech | 5 | 784 | 1153 | 323 | 1937 | 6.00 | 387.4 |
| 11 | Virginia | 5 | 696 | 1256 | 336 | 1952 | 5.81 | 390.4 |
| 12 | NC State | 4 | 694 | 955 | 260 | 1649 | 6.34 | 412.3 |
| 13 | North Carolina | 4 | 570 | 1120 | 279 | 1690 | 6.06 | 422.5 |
| 14 | Syracuse | 5 | 812 | 1312 | 347 | 2124 | 6.12 | 424.8 |
| 14 | Stanford | 5 | 674 | 1450 | 341 | 2124 | 6.23 | 424.8 |
| 16 | Boston College | 5 | 878 | 1280 | 358 | 2158 | 6.03 | 431.6 |
| 17 | SMU | 5 | 519 | 1693 | 395 | 2212 | 5.60 | 442.4 |