2025 Atlantic Coast Conference Leaders Total Defense - Games vs. FBS non-Power 5 Conference Teams Only through 09/11/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 1 | 32 | 177 | 68 | 209 | 3.07 | 209.0 |
| 2 | Virginia | 1 | 91 | 163 | 67 | 254 | 3.79 | 254.0 |
| 3 | Louisville | 1 | 126 | 137 | 78 | 263 | 3.37 | 263.0 |
| 4 | North Carolina | 1 | 21 | 250 | 71 | 271 | 3.82 | 271.0 |
| 5 | Clemson | 1 | 78 | 223 | 63 | 301 | 4.78 | 301.0 |
| 6 | Stanford | 1 | 96 | 210 | 64 | 306 | 4.78 | 306.0 |
| 7 | Wake Forest | 1 | 158 | 149 | 76 | 307 | 4.04 | 307.0 |
| 8 | Miami (FL) | 1 | 93 | 221 | 58 | 314 | 5.41 | 314.0 |
| 9 | NC State | 1 | 30 | 383 | 74 | 413 | 5.58 | 413.0 |
| 10 | Syracuse | 1 | 142 | 274 | 78 | 416 | 5.33 | 416.0 |