2025 Atlantic Coast Conference Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 10/02/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Miami (FL) | 1 | 93 | 221 | 58 | 314 | 5.41 | 314.0 |
| 2 | Clemson | 2 | 255 | 459 | 140 | 714 | 5.10 | 357.0 |
| 3 | Florida State | 2 | 298 | 483 | 156 | 781 | 5.01 | 390.5 |
| 4 | Wake Forest | 1 | 163 | 248 | 85 | 411 | 4.84 | 411.0 |
| 5 | Duke | 1 | 123 | 296 | 73 | 419 | 5.74 | 419.0 |
| 6 | Stanford | 2 | 363 | 559 | 142 | 922 | 6.49 | 461.0 |
| 7 | Virginia Tech | 1 | 262 | 228 | 57 | 490 | 8.60 | 490.0 |
| 8 | Syracuse | 1 | 246 | 247 | 68 | 493 | 7.25 | 493.0 |
| 9 | Virginia | 1 | 256 | 258 | 81 | 514 | 6.35 | 514.0 |
| 9 | NC State | 1 | 257 | 257 | 75 | 514 | 6.85 | 514.0 |