2025 Atlantic Coast Conference Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 10/24/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Syracuse | 1 | 246 | 247 | 68 | 493 | 7.25 | 493.0 |
| 2 | Wake Forest | 1 | 163 | 248 | 85 | 411 | 4.84 | 411.0 |
| 3 | Virginia | 1 | 54 | 329 | 75 | 383 | 5.11 | 383.0 |
| 4 | Pittsburgh | 1 | 53 | 339 | 85 | 392 | 4.61 | 392.0 |
| 5 | Louisville | 2 | 151 | 420 | 122 | 571 | 4.68 | 285.5 |
| 6 | Virginia Tech | 2 | 530 | 441 | 123 | 971 | 7.89 | 485.5 |
| 7 | Clemson | 2 | 255 | 459 | 140 | 714 | 5.10 | 357.0 |
| 8 | Duke | 2 | 294 | 501 | 130 | 795 | 6.12 | 397.5 |
| 9 | Stanford | 2 | 363 | 559 | 142 | 922 | 6.49 | 461.0 |
| 10 | NC State | 2 | 400 | 599 | 146 | 999 | 6.84 | 499.5 |
| 11 | Florida State | 3 | 395 | 724 | 215 | 1119 | 5.20 | 373.0 |
| 12 | Miami (FL) | 3 | 252 | 761 | 194 | 1013 | 5.22 | 337.7 |