2025 Big 12 Conference Leaders Long All Purpose Plays - Games in October Only through 11/18/2025
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Jayce Brown | Kansas St | JR | WR | 3 | 4 | 2 | 1 | 1 | 1 | 0 | 0 |
| 1 | Cameron Dickey | Texas Tech | SO | RB | 4 | 3 | 3 | 3 | 2 | 1 | 0 | 0 |
| 1 | Brett Eskildsen | Iowa State | SO | WR | 3 | 2 | 2 | 1 | 1 | 1 | 0 | 0 |
| 1 | Caleb Goodie | Cincinnati | JR | WR | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 1 | Parker Kingston | BYU | JR | WR | 4 | 4 | 3 | 2 | 1 | 1 | 0 | 0 |
| 1 | Eric McAlister | TCU | SR | WR | 4 | 2 | 1 | 1 | 1 | 1 | 1 | 0 |
| 1 | Matthew McDoom | Cincinnati | SR | CB | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 1 | Omarion Miller | Colorado | JR | WR | 3 | 3 | 1 | 1 | 1 | 1 | 0 | 0 |
| 1 | Jaden Nixon | UCF | SR | RB | 3 | 2 | 2 | 1 | 1 | 1 | 1 | 0 |
| 1 | Chase Roberts | BYU | SR | WR | 4 | 3 | 3 | 1 | 1 | 1 | 1 | 0 |
| 1 | Tre Spivey | Arizona | SO | WR | 3 | 2 | 2 | 1 | 1 | 1 | 0 | 0 |
| 1 | J'Koby Williams | Texas Tech | SO | RB | 4 | 4 | 2 | 2 | 1 | 1 | 1 | 1 |