2025 Big 12 Conference Leaders Long All Purpose Plays - Games at Home Only through 11/18/2025
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Emmanuel Henderson Jr. | Kansas | SR | WR | 6 | 6 | 6 | 5 | 4 | 3 | 2 | 2 |
| 1 | Jaden Nixon | UCF | SR | RB | 6 | 5 | 5 | 4 | 4 | 3 | 3 | 1 |
| 3 | Raleek Brown | Ariz St | JR | RB | 6 | 3 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Sincere Brown | Colorado | SR | WR | 6 | 3 | 2 | 2 | 2 | 1 | 0 | 0 |
| 3 | Mana Carvalho | Utah | FR | WR | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Cameron Dickey | Texas Tech | SO | RB | 7 | 3 | 2 | 2 | 1 | 1 | 0 | 0 |
| 3 | Dylan Edwards | Kansas St | JR | RB | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Brett Eskildsen | Iowa State | SO | WR | 5 | 4 | 3 | 2 | 2 | 1 | 0 | 0 |
| 3 | Caleb Goodie | Cincinnati | JR | WR | 6 | 3 | 3 | 2 | 1 | 1 | 1 | 0 |
| 3 | Eric McAlister | TCU | SR | WR | 5 | 5 | 3 | 1 | 1 | 1 | 0 | 0 |
| 3 | Omarion Miller | Colorado | JR | WR | 5 | 3 | 2 | 2 | 1 | 1 | 0 | 0 |
| 3 | Bryce Noernberg | Kansas St | FR | WR | 4 | 3 | 2 | 1 | 1 | 1 | 1 | 1 |
| 3 | Chase Roberts | BYU | SR | WR | 5 | 3 | 3 | 1 | 1 | 1 | 1 | 0 |
| 3 | Joe Royer | Cincinnati | SR | TE | 6 | 3 | 2 | 2 | 2 | 1 | 0 | 0 |
| 3 | Javin Whatley | Arizona | SR | WR | 6 | 2 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | J'Koby Williams | Texas Tech | SO | RB | 7 | 6 | 2 | 1 | 1 | 1 | 1 | 1 |