2025 Big 12 Conference Leaders Long All Purpose Plays - Games vs. FBS Power 5 Conference Teams Only through 12/06/2025
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Emmanuel Henderson Jr. | Kansas | SR | WR | 10 | 7 | 6 | 5 | 3 | 3 | 2 | 2 |
| 2 | Jayce Brown | Kansas St | JR | WR | 8 | 11 | 4 | 3 | 2 | 2 | 0 | 0 |
| 2 | Eric McAlister | TCU | SR | WR | 11 | 9 | 5 | 2 | 2 | 2 | 1 | 0 |
| 2 | J'Koby Williams | Texas Tech | SO | RB | 11 | 10 | 5 | 3 | 2 | 2 | 1 | 1 |
| 5 | Cyrus Allen | Cincinnati | SR | WR | 10 | 5 | 2 | 1 | 1 | 1 | 1 | 0 |
| 5 | Kevorian Barnes | TCU | SR | RB | 6 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 5 | DJ Black | UCF | JR | WR | 10 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 5 | Cyncir Bowers | WVU | SO | RB | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Raleek Brown | Ariz St | JR | RB | 10 | 5 | 2 | 2 | 1 | 1 | 1 | 0 |
| 5 | Mana Carvalho | Utah | FR | WR | 8 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 5 | Elijah Davis | Utah | JR | CB | 10 | 2 | 2 | 2 | 2 | 1 | 1 | 1 |
| 5 | Cameron Dickey | Texas Tech | SO | RB | 11 | 4 | 3 | 3 | 2 | 1 | 0 | 0 |
| 5 | Dylan Edwards | Kansas St | JR | RB | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 5 | Brett Eskildsen | Iowa State | SO | WR | 10 | 4 | 3 | 1 | 1 | 1 | 0 | 0 |
| 5 | Byrd Ficklin | Utah | FR | QB | 10 | 3 | 3 | 3 | 3 | 1 | 0 | 0 |
| 5 | Aiden Flora | Iowa State | FR | RB | 9 | 3 | 1 | 1 | 1 | 1 | 0 | 0 |
| 5 | Caleb Goodie | Cincinnati | JR | WR | 9 | 2 | 2 | 1 | 1 | 1 | 1 | 0 |
| 5 | Joe Jackson | Kansas St | SO | RB | 10 | 4 | 3 | 2 | 2 | 1 | 1 | 0 |
| 5 | Parker Kingston | BYU | JR | WR | 11 | 7 | 5 | 3 | 1 | 1 | 0 | 0 |
| 5 | Matthew McDoom | Cincinnati | SR | CB | 10 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Omarion Miller | Colorado | JR | WR | 10 | 9 | 4 | 2 | 1 | 1 | 0 | 0 |
| 5 | Jaden Nixon | UCF | SR | RB | 10 | 3 | 3 | 2 | 1 | 1 | 1 | 0 |
| 5 | Kobe Prentice | Baylor | SR | WR | 10 | 5 | 2 | 1 | 1 | 1 | 0 | 0 |
| 5 | Chase Roberts | BYU | SR | WR | 10 | 4 | 4 | 1 | 1 | 1 | 1 | 0 |
| 5 | Jordan Scruggs | WVU | SR | CB | 10 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 5 | Jeff Sims | Ariz St | SR | QB | 7 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 5 | Tre Spivey | Arizona | SO | WR | 10 | 3 | 3 | 2 | 1 | 1 | 0 | 0 |
| 5 | Dylan Wade | UCF | JR | TE | 9 | 3 | 2 | 2 | 1 | 1 | 1 | 0 |
| 5 | Jeff Weimer | WVU | SR | WR | 10 | 3 | 2 | 2 | 1 | 1 | 0 | 0 |