2021 Big 12 Conference Leaders Long All Purpose Plays - Games at Home Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | LD Brown | Okla St | SR | RB | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 1 | Leddie Brown | WVU | SR | RB | 6 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 1 | Derius Davis | TCU | SR | WR | 7 | 5 | 5 | 2 | 2 | 1 | 1 | 1 |
| 1 | Trestan Ebner | Baylor | SR | RB | 7 | 8 | 5 | 3 | 2 | 1 | 1 | 1 |
| 1 | Erik Ezukanma | Texas Tech | JR | WR | 6 | 4 | 3 | 2 | 1 | 1 | 0 | 0 |
| 1 | Breece Hall | Iowa State | JR | RB | 6 | 6 | 2 | 1 | 1 | 1 | 1 | 0 |
| 1 | Daniel Imatorbhebhe | Kansas St | SR | TE | 7 | 2 | 2 | 2 | 2 | 1 | 0 | 0 |
| 1 | Roschon Johnson | Texas | JR | RB | 6 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 1 | Malik Knowles | Kansas St | JR | WR | 7 | 7 | 5 | 3 | 2 | 1 | 1 | 1 |
| 1 | Kenny Logan Jr. | Kansas | JR | S | 6 | 2 | 2 | 2 | 2 | 1 | 1 | 0 |
| 1 | Brennan Presley | Okla St | SO | WR | 7 | 7 | 2 | 1 | 1 | 1 | 1 | 1 |
| 1 | Abram Smith | Baylor | SR | RB | 7 | 7 | 1 | 1 | 1 | 1 | 0 | 0 |
| 1 | JD Spielman | TCU | SR | WR | 4 | 5 | 3 | 2 | 1 | 1 | 1 | 0 |
| 1 | SaRodorick Thompson | Texas Tech | JR | RB | 5 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 1 | Tyquan Thornton | Baylor | SR | WR | 7 | 4 | 4 | 1 | 1 | 1 | 0 | 0 |
| 1 | Marquis Waters | Texas Tech | SR | DB | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 1 | Caleb Williams | Oklahoma | FR | QB | 5 | 3 | 3 | 2 | 1 | 1 | 0 | 0 |
| 1 | JT Woods | Baylor | SR | S | 7 | 2 | 2 | 1 | 1 | 1 | 1 | 1 |
| 1 | Winston Wright Jr. | WVU | JR | WR | 6 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |