2025 Conference USA Leaders Opponent First Downs - Games vs. FBS non-Power 5 Conference Teams Only through 11/01/2025
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Liberty | 7 | 68 | 59 | 7 | 134 | 19.1 |
| 2 | Delaware | 6 | 45 | 79 | 8 | 132 | 22.0 |
| 3 | Kennesaw State | 5 | 38 | 56 | 9 | 103 | 20.6 |
| 4 | Jacksonville State | 6 | 53 | 61 | 10 | 124 | 20.7 |
| 5 | FIU | 6 | 51 | 63 | 11 | 125 | 20.8 |
| 6 | Missouri State | 5 | 33 | 57 | 12 | 102 | 20.4 |
| 6 | Middle Tennessee State | 6 | 54 | 57 | 12 | 123 | 20.5 |
| 8 | Louisiana Tech | 6 | 37 | 70 | 13 | 120 | 20.0 |
| 8 | Sam Houston State | 7 | 70 | 82 | 13 | 165 | 23.6 |
| 10 | UTEP | 6 | 47 | 51 | 14 | 112 | 18.7 |
| 10 | New Mexico State | 7 | 59 | 86 | 14 | 159 | 22.7 |
| 12 | Western Kentucky | 8 | 61 | 79 | 24 | 164 | 20.5 |