2025 Conference USA Leaders Opponent First Downs - Games vs. Conference Teams Only through 11/01/2025
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Liberty | 4 | 36 | 30 | 2 | 68 | 17.0 |
| 2 | Delaware | 5 | 39 | 59 | 5 | 103 | 20.6 |
| 3 | FIU | 4 | 36 | 38 | 6 | 80 | 20.0 |
| 3 | Kennesaw State | 4 | 33 | 46 | 6 | 85 | 21.3 |
| 5 | Jacksonville State | 4 | 25 | 43 | 7 | 75 | 18.8 |
| 5 | New Mexico State | 5 | 44 | 60 | 7 | 111 | 22.2 |
| 7 | Louisiana Tech | 5 | 32 | 51 | 8 | 91 | 18.2 |
| 7 | Middle Tennessee State | 4 | 31 | 41 | 8 | 80 | 20.0 |
| 9 | Sam Houston State | 5 | 56 | 55 | 10 | 121 | 24.2 |
| 10 | UTEP | 4 | 31 | 34 | 11 | 76 | 19.0 |
| 10 | Missouri State | 4 | 26 | 53 | 11 | 90 | 22.5 |
| 12 | Western Kentucky | 6 | 42 | 63 | 16 | 121 | 20.2 |