2025 Conference USA Leaders Opponent First Downs - Games vs. FBS non-Power 5 Conference Teams Only through 12/13/2025
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Missouri State | 9 | 75 | 92 | 19 | 186 | 20.7 |
| 2 | Louisiana Tech | 9 | 66 | 95 | 25 | 186 | 20.7 |
| 3 | Liberty | 11 | 110 | 98 | 19 | 227 | 20.6 |
| 4 | Western Kentucky | 10 | 76 | 101 | 31 | 208 | 20.8 |
| 5 | Kennesaw State | 10 | 91 | 102 | 22 | 215 | 21.5 |
| 6 | FIU | 10 | 91 | 104 | 15 | 210 | 21.0 |
| 7 | UTEP | 10 | 78 | 108 | 25 | 211 | 21.1 |
| 8 | Delaware | 9 | 61 | 110 | 21 | 192 | 21.3 |
| 9 | Jacksonville State | 11 | 102 | 113 | 24 | 239 | 21.7 |
| 9 | Middle Tennessee State | 10 | 82 | 113 | 24 | 219 | 21.9 |
| 11 | New Mexico State | 10 | 86 | 116 | 18 | 220 | 22.0 |
| 12 | Sam Houston State | 10 | 97 | 119 | 21 | 237 | 23.7 |