2025 Conference USA Leaders Opponent First Downs - Games vs. FBS Power 5 Conference Teams Only through 09/06/2025
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | FIU | 1 | 10 | 9 | 1 | 20 | 20.0 |
| 1 | Middle Tennessee State | 1 | 6 | 14 | 1 | 21 | 21.0 |
| 3 | Delaware | 1 | 9 | 10 | 2 | 21 | 21.0 |
| 3 | Jacksonville State | 1 | 9 | 12 | 2 | 23 | 23.0 |
| 5 | Kennesaw State | 2 | 22 | 23 | 3 | 48 | 24.0 |
| 6 | Missouri State | 1 | 8 | 15 | 4 | 27 | 27.0 |
| 7 | Louisiana Tech | 1 | 6 | 15 | 6 | 27 | 27.0 |