2021 American Athletic Conference Leaders Interceptions - Games in October Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Coby Bryant | Cincinnati | SR | CB | 5 | 3 | 95 | 1 | 0.60 |
| 2 | Antonio Grier | S Florida | SR | LB | 4 | 2 | 69 | 1 | 0.50 |
| 3 | Gervarrius Owens | Houston | JR | S | 4 | 1 | 45 | 1 | 0.25 |
| 4 | Travon Fuller | Tulsa | SR | CB | 4 | 1 | 44 | 0 | 0.25 |
| 5 | Dyllon Lester | UCF | JR | DB | 5 | 1 | 34 | 0 | 0.20 |
| 6 | Shawn Dourseau | ECU | SO | SAF | 4 | 1 | 33 | 0 | 0.25 |
| 6 | Macon Clark | Tulane | JR | S | 4 | 1 | 33 | 0 | 0.25 |
| 8 | Deshawn Pace | Cincinnati | SO | LB | 5 | 2 | 31 | 0 | 0.40 |
| 8 | Malik Fleming | ECU | SO | CB | 4 | 1 | 31 | 1 | 0.25 |
| 8 | Warren Saba | ECU | SR | SAF | 4 | 1 | 31 | 0 | 0.25 |
| 11 | Divaad Wilson | UCF | JR | DB | 5 | 1 | 25 | 0 | 0.20 |
| 12 | Davonte Brown | UCF | SO | DB | 5 | 1 | 14 | 0 | 0.20 |
| 13 | Jeremiah Jean-Baptiste | UCF | JR | LB | 5 | 1 | 8 | 0 | 0.20 |
| 14 | Ja'von Hicks | Cincinnati | SR | S | 5 | 1 | 7 | 0 | 0.20 |
| 15 | Teagan Wilk | ECU | FR | SAF | 4 | 1 | 6 | 0 | 0.25 |
| 16 | Dwayne Boyles | S Florida | SR | LB | 4 | 2 | 4 | 0 | 0.50 |
| 16 | Juan Powell | ECU | FR | SAF | 4 | 1 | 4 | 0 | 0.25 |
| 16 | Ahmad Gardner | Cincinnati | JR | CB | 5 | 1 | 4 | 0 | 0.20 |
| 19 | Arquon Bush | Cincinnati | JR | CB | 4 | 1 | 1 | 0 | 0.25 |
| 19 | Jamal Glenn | Navy | SR | CB | 4 | 1 | 1 | 0 | 0.25 |