2021 American Athletic Conference Leaders Interceptions - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Coby Bryant | Cincinnati | SR | CB | 8 | 1 | 74 | 1 | 0.13 |
| 2 | Antonio Grier | S Florida | SR | LB | 8 | 1 | 69 | 1 | 0.13 |
| 3 | Christian Williams | S Florida | SO | S | 6 | 1 | 61 | 0 | 0.17 |
| 4 | Justin Wright | Tulsa | JR | LB | 5 | 1 | 55 | 1 | 0.20 |
| 5 | Macon Clark | Tulane | JR | S | 9 | 3 | 45 | 0 | 0.33 |
| 5 | Gervarrius Owens | Houston | JR | S | 5 | 1 | 45 | 1 | 0.20 |
| 7 | Deshawn Pace | Cincinnati | SO | LB | 8 | 2 | 31 | 0 | 0.25 |
| 8 | Matthew Hill | S Florida | SO | S | 6 | 1 | 27 | 0 | 0.17 |
| 9 | Rodney Owens | Memphis | SR | DB | 7 | 2 | 25 | 0 | 0.29 |
| 9 | Freddie Johnson | Temple | SR | CB | 5 | 1 | 25 | 0 | 0.20 |
| 11 | Tatum Bethune | UCF | JR | LB | 4 | 1 | 23 | 0 | 0.25 |
| 12 | Jalen Ware | Temple | JR | SAF | 3 | 2 | 20 | 0 | 0.67 |
| 12 | Ja'Quan McMillian | ECU | SO | CB | 6 | 2 | 20 | 0 | 0.33 |
| 14 | Travon Fuller | Tulsa | SR | CB | 5 | 2 | 16 | 0 | 0.40 |
| 15 | Kevin Brennan | Navy | SR | FS | 5 | 1 | 15 | 0 | 0.20 |
| 16 | Lance Robinson | Tulane | SO | DB | 6 | 1 | 13 | 0 | 0.17 |
| 17 | Trevor Denbow | SMU | SR | S | 4 | 1 | 11 | 0 | 0.25 |
| 18 | Joel Dublanko | Cincinnati | SR | LB | 8 | 1 | 9 | 0 | 0.13 |
| 19 | Jeremiah Jean-Baptiste | UCF | JR | LB | 4 | 1 | 8 | 0 | 0.25 |
| 20 | Mbiti Williams Jr. | Navy | FR | CB | 8 | 1 | 7 | 0 | 0.13 |
| 21 | Dwayne Boyles | S Florida | SR | LB | 8 | 2 | 4 | 0 | 0.25 |
| 21 | Juan Powell | ECU | FR | SAF | 6 | 1 | 4 | 0 | 0.17 |
| 21 | Ahmad Gardner | Cincinnati | JR | CB | 8 | 1 | 4 | 0 | 0.13 |
| 21 | Kevin Henry | Tulane | SR | LB | 9 | 1 | 4 | 0 | 0.11 |
| 25 | Jacobi Francis | Memphis | SR | DB | 7 | 2 | 1 | 0 | 0.29 |
| 25 | Jamal Glenn | Navy | SR | CB | 10 | 1 | 1 | 0 | 0.10 |