2021 American Athletic Conference Leaders Interceptions - Games on the Road/Neutral Site Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Alex Hogan | Houston | JR | CB | 9 | 2 | 91 | 1 | 0.22 |
| 2 | Deshawn Pace | Cincinnati | SO | LB | 7 | 3 | 74 | 0 | 0.43 |
| 3 | Gervarrius Owens | Houston | JR | S | 8 | 2 | 73 | 1 | 0.25 |
| 4 | Justin Wright | Tulsa | JR | LB | 7 | 1 | 55 | 1 | 0.14 |
| 5 | Gleson Sprewell | Houston | SR | S | 7 | 2 | 44 | 0 | 0.29 |
| 6 | Isaac Slade-Matautia | SMU | JR | LB | 6 | 1 | 35 | 0 | 0.17 |
| 7 | Jalen Ware | Temple | JR | SAF | 4 | 1 | 27 | 0 | 0.25 |
| 7 | Matthew Hill | S Florida | SO | S | 5 | 1 | 27 | 0 | 0.20 |
| 9 | Rodney Owens | Memphis | SR | DB | 5 | 1 | 25 | 0 | 0.20 |
| 9 | Freddie Johnson | Temple | SR | CB | 6 | 1 | 25 | 0 | 0.17 |
| 11 | Tatum Bethune | UCF | JR | LB | 5 | 1 | 23 | 0 | 0.20 |
| 12 | Ja'Quan McMillian | ECU | SO | CB | 6 | 3 | 22 | 0 | 0.50 |
| 13 | Travon Fuller | Tulsa | SR | CB | 7 | 2 | 16 | 0 | 0.29 |
| 14 | Delano Robinson | SMU | SR | LB | 6 | 1 | 8 | 0 | 0.17 |
| 15 | Ahmad Gardner | Cincinnati | JR | CB | 7 | 2 | 7 | 0 | 0.29 |
| 15 | Manny Walker | Temple | SR | DE | 6 | 1 | 7 | 1 | 0.17 |
| 15 | Ja'von Hicks | Cincinnati | SR | S | 7 | 1 | 7 | 0 | 0.14 |
| 18 | Arquon Bush | Cincinnati | JR | CB | 6 | 2 | 5 | 0 | 0.33 |
| 19 | Juan Powell | ECU | FR | SAF | 4 | 1 | 4 | 0 | 0.25 |
| 20 | Marcus Jones | Houston | SR | CB | 8 | 2 | 2 | 0 | 0.25 |