2021 American Athletic Conference Leaders Interceptions - Games in October Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Coby Bryant | Cincinnati | SR | CB | 5 | 3 | 95 | 1 | 0.60 |
| 1 | Antonio Grier | S Florida | SR | LB | 4 | 2 | 69 | 1 | 0.50 |
| 1 | Gervarrius Owens | Houston | JR | S | 4 | 1 | 45 | 1 | 0.25 |
| 1 | Malik Fleming | ECU | SO | CB | 4 | 1 | 31 | 1 | 0.25 |