2021 American Athletic Conference Leaders Interceptions - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Alex Hogan | Houston | JR | CB | 8 | 1 | 91 | 1 | 0.13 |
| 2 | Mekhi LaPointe | S Florida | SR | DB | 3 | 2 | 50 | 0 | 0.67 |
| 3 | Deshawn Pace | Cincinnati | SO | LB | 5 | 2 | 47 | 0 | 0.40 |
| 4 | Gleson Sprewell | Houston | SR | S | 7 | 2 | 44 | 0 | 0.29 |
| 4 | Travon Fuller | Tulsa | SR | CB | 7 | 1 | 44 | 0 | 0.14 |
| 6 | Brock Nichols | S Florida | SR | S | 2 | 1 | 38 | 0 | 0.50 |
| 7 | Dyllon Lester | UCF | JR | DB | 7 | 1 | 34 | 0 | 0.14 |
| 8 | Macon Clark | Tulane | JR | S | 2 | 1 | 33 | 0 | 0.50 |
| 8 | Shawn Dourseau | ECU | SO | SAF | 5 | 1 | 33 | 0 | 0.20 |
| 10 | Malik Fleming | ECU | SO | CB | 5 | 1 | 31 | 1 | 0.20 |
| 10 | Warren Saba | ECU | SR | SAF | 5 | 1 | 31 | 0 | 0.20 |
| 12 | Gervarrius Owens | Houston | JR | S | 7 | 1 | 28 | 0 | 0.14 |
| 13 | Isaac Slade-Matautia | SMU | JR | LB | 7 | 2 | 27 | 0 | 0.29 |
| 14 | Divaad Wilson | UCF | JR | DB | 8 | 2 | 25 | 0 | 0.25 |
| 15 | Coby Bryant | Cincinnati | SR | CB | 5 | 2 | 21 | 0 | 0.40 |
| 16 | Isaiah Nwokobia | SMU | FR | S | 6 | 1 | 17 | 0 | 0.17 |
| 17 | Quindell Johnson | Memphis | JR | DB | 4 | 1 | 14 | 0 | 0.25 |
| 17 | Davonte Brown | UCF | SO | DB | 8 | 1 | 14 | 0 | 0.13 |
| 19 | Cam Goode | UCF | JR | DL | 8 | 1 | 10 | 0 | 0.13 |
| 20 | Delano Robinson | SMU | SR | LB | 7 | 1 | 8 | 0 | 0.14 |
| 21 | Ja'von Hicks | Cincinnati | SR | S | 5 | 1 | 7 | 0 | 0.20 |
| 21 | Manny Walker | Temple | SR | DE | 6 | 1 | 7 | 1 | 0.17 |
| 23 | Teagan Wilk | ECU | FR | SAF | 5 | 1 | 6 | 0 | 0.20 |
| 24 | Arquon Bush | Cincinnati | JR | CB | 4 | 2 | 5 | 0 | 0.50 |
| 25 | Ahmad Gardner | Cincinnati | JR | CB | 5 | 1 | 3 | 0 | 0.20 |
| 26 | Marcus Jones | Houston | SR | CB | 7 | 4 | 2 | 0 | 0.57 |