2021 American Athletic Conference Leaders Interceptions - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Justin Wright | Tulsa | JR | LB | 2 | 1 | 55 | 1 | 0.50 |
| 2 | Mekhi LaPointe | S Florida | SR | DB | 2 | 1 | 50 | 0 | 0.50 |
| 3 | Deshawn Pace | Cincinnati | SO | LB | 2 | 1 | 39 | 0 | 0.50 |
| 4 | Brock Nichols | S Florida | SR | S | 2 | 1 | 38 | 0 | 0.50 |
| 5 | Matthew Hill | S Florida | SO | S | 2 | 1 | 27 | 0 | 0.50 |
| 6 | Arquon Bush | Cincinnati | JR | CB | 2 | 1 | 4 | 0 | 0.50 |