2021 Big 12 Conference Leaders Interceptions - Games in November Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Woodi Washington | Oklahoma | SO | CB | 3 | 2 | 32 | 0 | 0.67 |
| 2 | Jacobee Bryant | Kansas | FR | CB | 4 | 2 | 31 | 1 | 0.50 |
| 3 | Gavin Potter | Kansas | JR | LB | 4 | 1 | 28 | 1 | 0.25 |
| 3 | Sean Mahone | WVU | SR | S | 4 | 1 | 28 | 0 | 0.25 |
| 5 | Aric Horne | Iowa State | SO | LB | 4 | 1 | 14 | 0 | 0.25 |
| 6 | Colin Schooler | Texas Tech | SR | LB | 3 | 1 | 11 | 0 | 0.33 |
| 7 | Al Walcott | Baylor | JR | CB | 4 | 2 | 5 | 0 | 0.50 |
| 8 | Russ Yeast | Kansas St | SR | DB | 4 | 1 | 3 | 0 | 0.25 |
| 9 | Craig McDonald | Iowa State | FR | DB | 4 | 1 | 2 | 0 | 0.25 |
| 9 | Christian Holmes | Okla St | SR | CB | 4 | 1 | 2 | 0 | 0.25 |
| 9 | Dee Winters | TCU | JR | LB | 4 | 1 | 2 | 0 | 0.25 |