2021 Big 12 Conference Leaders Interceptions - Games in August/September Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Marquis Waters | Texas Tech | SR | DB | 4 | 1 | 72 | 1 | 0.25 |
| 2 | Ra'Mello Dotson | Kansas | FR | CB | 4 | 1 | 65 | 0 | 0.25 |
| 3 | Wyatt Harris | TCU | JR | LB | 3 | 1 | 47 | 0 | 0.33 |
| 4 | TJ Smith | Kansas St | FR | DB | 4 | 1 | 39 | 0 | 0.25 |
| 5 | Bryson Washington | Oklahoma | FR | S | 4 | 1 | 37 | 0 | 0.25 |
| 6 | Josh Thompson | Texas | SR | DB | 4 | 1 | 27 | 1 | 0.25 |
| 7 | Tee Denson | Kansas St | SO | DB | 4 | 1 | 26 | 0 | 0.25 |
| 8 | JT Woods | Baylor | SR | S | 4 | 1 | 20 | 1 | 0.25 |
| 8 | Jalen Pitre | Baylor | SR | S | 4 | 1 | 20 | 0 | 0.25 |
| 10 | Datrone Young | Iowa State | SR | DB | 3 | 1 | 15 | 0 | 0.33 |
| 10 | Luke Brockermeyer | Texas | JR | LB | 4 | 1 | 15 | 0 | 0.25 |
| 12 | Riko Jeffers | Texas Tech | SR | LB | 4 | 1 | 13 | 1 | 0.25 |
| 13 | B.J. Foster | Texas | SR | DB | 4 | 1 | 9 | 0 | 0.25 |
| 14 | Isheem Young | Iowa State | SO | DB | 4 | 2 | 5 | 0 | 0.50 |
| 14 | Dee Winters | TCU | JR | LB | 3 | 1 | 5 | 0 | 0.33 |
| 16 | Garmon Randolph | Baylor | SO | OLB | 2 | 1 | 2 | 0 | 0.50 |
| 17 | Kolby Harvell-Peel | Okla St | SR | S | 4 | 2 | 1 | 0 | 0.50 |