2021 Big 12 Conference Leaders Interceptions - Games at Home Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Marquis Waters | Texas Tech | SR | DB | 2 | 1 | 72 | 1 | 0.50 |
| 2 | Wyatt Harris | TCU | JR | LB | 5 | 1 | 47 | 0 | 0.20 |
| 3 | JT Woods | Baylor | SR | S | 7 | 1 | 40 | 0 | 0.14 |
| 4 | Bryson Washington | Oklahoma | FR | S | 6 | 1 | 37 | 0 | 0.17 |
| 5 | Sean Mahone | WVU | SR | S | 6 | 2 | 29 | 0 | 0.33 |
| 6 | Gavin Potter | Kansas | JR | LB | 6 | 1 | 28 | 1 | 0.17 |
| 7 | Nick Session | Okla St | FR | S | 3 | 1 | 27 | 0 | 0.33 |
| 7 | Josh Thompson | Texas | SR | DB | 5 | 1 | 27 | 1 | 0.20 |
| 9 | Tee Denson | Kansas St | SO | DB | 7 | 1 | 26 | 0 | 0.14 |
| 10 | Kenny Logan Jr. | Kansas | JR | S | 6 | 1 | 22 | 0 | 0.17 |
| 11 | Kolby Harvell-Peel | Okla St | SR | S | 7 | 2 | 21 | 0 | 0.29 |
| 11 | Patrick Fields | Oklahoma | SR | S | 7 | 2 | 21 | 0 | 0.29 |
| 13 | Luke Brockermeyer | Texas | JR | LB | 5 | 1 | 15 | 0 | 0.20 |
| 13 | Datrone Young | Iowa State | SR | DB | 6 | 1 | 15 | 0 | 0.17 |
| 15 | Colin Schooler | Texas Tech | SR | LB | 6 | 1 | 11 | 0 | 0.17 |
| 16 | Dee Winters | TCU | JR | LB | 7 | 2 | 7 | 0 | 0.29 |
| 17 | Russ Yeast | Kansas St | SR | DB | 7 | 1 | 3 | 0 | 0.14 |
| 18 | Garmon Randolph | Baylor | SO | OLB | 6 | 1 | 2 | 0 | 0.17 |
| 18 | Justin Broiles | Oklahoma | SR | DB | 7 | 1 | 2 | 0 | 0.14 |