2021 Big 12 Conference Leaders Interceptions - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Al Walcott | Baylor | JR | CB | 8 | 3 | 101 | 1 | 0.38 |
| 2 | JT Woods | Baylor | SR | S | 8 | 4 | 49 | 0 | 0.50 |
| 3 | Wyatt Harris | TCU | JR | LB | 4 | 1 | 47 | 0 | 0.25 |
| 4 | B.J. Foster | Texas | SR | DB | 8 | 3 | 40 | 0 | 0.38 |
| 5 | Woodi Washington | Oklahoma | SO | CB | 4 | 2 | 32 | 0 | 0.50 |
| 6 | Tre'Vius Hodges-Tomlinson | TCU | JR | CB | 7 | 1 | 29 | 1 | 0.14 |
| 7 | Josh Thompson | Texas | SR | DB | 7 | 1 | 27 | 1 | 0.14 |
| 8 | Tee Denson | Kansas St | SO | DB | 6 | 1 | 26 | 0 | 0.17 |
| 9 | Luke Brockermeyer | Texas | JR | LB | 7 | 2 | 24 | 0 | 0.29 |
| 10 | Kenny Logan Jr. | Kansas | JR | S | 7 | 1 | 22 | 0 | 0.14 |
| 11 | Patrick Fields | Oklahoma | SR | S | 6 | 2 | 21 | 0 | 0.33 |
| 12 | Greg Eisworth II | Iowa State | SR | DB | 7 | 1 | 18 | 0 | 0.14 |
| 13 | Brayden Utley | Baylor | JR | DL | 8 | 1 | 15 | 0 | 0.13 |
| 14 | Justin Broiles | Oklahoma | SR | DB | 6 | 2 | 14 | 0 | 0.33 |
| 14 | Aric Horne | Iowa State | SO | LB | 6 | 1 | 14 | 0 | 0.17 |
| 16 | Riko Jeffers | Texas Tech | SR | LB | 7 | 1 | 13 | 1 | 0.14 |
| 17 | Colin Schooler | Texas Tech | SR | LB | 7 | 1 | 11 | 0 | 0.14 |
| 17 | Malcolm Rodriguez | Okla St | SR | LB | 9 | 1 | 11 | 0 | 0.11 |
| 19 | Russ Yeast | Kansas St | SR | DB | 6 | 1 | 10 | 0 | 0.17 |
| 20 | Dee Winters | TCU | JR | LB | 7 | 1 | 5 | 0 | 0.14 |
| 20 | Dillon Doyle | Baylor | JR | LB | 8 | 1 | 5 | 0 | 0.13 |
| 22 | Garmon Randolph | Baylor | SO | OLB | 7 | 1 | 2 | 0 | 0.14 |
| 22 | Craig McDonald | Iowa State | FR | DB | 7 | 1 | 2 | 0 | 0.14 |
| 22 | Raleigh Texada | Baylor | SR | CB | 8 | 1 | 2 | 0 | 0.13 |
| 25 | Kolby Harvell-Peel | Okla St | SR | S | 9 | 2 | 1 | 0 | 0.22 |
| 25 | Sean Mahone | WVU | SR | S | 8 | 1 | 1 | 0 | 0.13 |