2021 Big 12 Conference Leaders Interceptions - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | JT Woods | Baylor | SR | S | 13 | 6 | 109 | 1 | 0.46 |
| 2 | Al Walcott | Baylor | JR | CB | 12 | 3 | 101 | 1 | 0.25 |
| 3 | Jason Taylor II | Okla St | JR | S | 13 | 2 | 85 | 1 | 0.15 |
| 4 | Marquis Waters | Texas Tech | SR | DB | 3 | 1 | 72 | 1 | 0.33 |
| 5 | Ra'Mello Dotson | Kansas | FR | CB | 11 | 1 | 65 | 0 | 0.09 |
| 6 | Wyatt Harris | TCU | JR | LB | 7 | 1 | 47 | 0 | 0.14 |
| 7 | Daryl Porter Jr. | WVU | FR | CB | 12 | 1 | 43 | 0 | 0.08 |
| 8 | B.J. Foster | Texas | SR | DB | 12 | 3 | 40 | 0 | 0.25 |
| 9 | TJ Smith | Kansas St | FR | DB | 12 | 2 | 39 | 0 | 0.17 |
| 10 | Woodi Washington | Oklahoma | SO | CB | 5 | 2 | 32 | 0 | 0.40 |
| 10 | Charles Woods | WVU | JR | CB | 10 | 2 | 32 | 0 | 0.20 |
| 10 | Ross Elder | Kansas St | SR | DB | 12 | 1 | 32 | 0 | 0.08 |
| 13 | Jacobee Bryant | Kansas | FR | CB | 10 | 2 | 31 | 1 | 0.20 |
| 14 | Sean Mahone | WVU | SR | S | 12 | 2 | 29 | 0 | 0.17 |
| 14 | Tre'Vius Hodges-Tomlinson | TCU | JR | CB | 11 | 1 | 29 | 1 | 0.09 |
| 16 | Gavin Potter | Kansas | JR | LB | 11 | 1 | 28 | 1 | 0.09 |
| 17 | Nick Session | Okla St | FR | S | 5 | 1 | 27 | 0 | 0.20 |
| 17 | Josh Thompson | Texas | SR | DB | 9 | 1 | 27 | 1 | 0.11 |
| 19 | Tee Denson | Kansas St | SO | DB | 11 | 1 | 26 | 0 | 0.09 |
| 20 | Luke Brockermeyer | Texas | JR | LB | 11 | 2 | 24 | 0 | 0.18 |
| 20 | Jake Hummel | Iowa State | SR | LB | 12 | 2 | 24 | 1 | 0.17 |
| 22 | Kenny Logan Jr. | Kansas | JR | S | 11 | 1 | 22 | 0 | 0.09 |
| 23 | Kolby Harvell-Peel | Okla St | SR | S | 13 | 3 | 21 | 0 | 0.23 |
| 23 | Patrick Fields | Oklahoma | SR | S | 12 | 2 | 21 | 0 | 0.17 |
| 25 | Jalen Pitre | Baylor | SR | S | 13 | 2 | 20 | 0 | 0.15 |
| 26 | Greg Eisworth II | Iowa State | SR | DB | 12 | 2 | 18 | 0 | 0.17 |
| 27 | Brayden Utley | Baylor | JR | DL | 13 | 1 | 15 | 0 | 0.08 |
| 28 | Justin Broiles | Oklahoma | SR | DB | 12 | 2 | 14 | 0 | 0.17 |
| 28 | Aric Horne | Iowa State | SO | LB | 11 | 1 | 14 | 0 | 0.09 |
| 30 | Riko Jeffers | Texas Tech | SR | LB | 12 | 1 | 13 | 1 | 0.08 |
| 30 | Tanner McCalister | Okla St | SR | S | 13 | 1 | 13 | 0 | 0.08 |
| 32 | Russ Yeast | Kansas St | SR | DB | 12 | 4 | 11 | 0 | 0.33 |
| 32 | Malcolm Rodriguez | Okla St | SR | LB | 13 | 1 | 11 | 0 | 0.08 |
| 32 | Colin Schooler | Texas Tech | SR | LB | 12 | 1 | 11 | 0 | 0.08 |
| 35 | Dee Winters | TCU | JR | LB | 11 | 2 | 7 | 0 | 0.18 |
| 36 | Isheem Young | Iowa State | SO | DB | 11 | 1 | 5 | 0 | 0.09 |
| 36 | Dillon Doyle | Baylor | JR | LB | 13 | 1 | 5 | 0 | 0.08 |
| 38 | Dadrion Taylor-Demerson | Texas Tech | JR | DB | 11 | 3 | 4 | 0 | 0.27 |
| 39 | Craig McDonald | Iowa State | FR | DB | 12 | 2 | 2 | 0 | 0.17 |
| 39 | Garmon Randolph | Baylor | SO | OLB | 11 | 1 | 2 | 0 | 0.09 |
| 39 | Raleigh Texada | Baylor | SR | CB | 13 | 1 | 2 | 0 | 0.08 |
| 39 | Christian Holmes | Okla St | SR | CB | 13 | 1 | 2 | 0 | 0.08 |