2021 Big 12 Conference Leaders Interceptions - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Jason Taylor II | Okla St | JR | S | 4 | 2 | 85 | 1 | 0.50 |
| 2 | Marquis Waters | Texas Tech | SR | DB | 2 | 1 | 72 | 1 | 0.50 |
| 3 | Ra'Mello Dotson | Kansas | FR | CB | 4 | 1 | 65 | 0 | 0.25 |
| 4 | JT Woods | Baylor | SR | S | 5 | 2 | 60 | 1 | 0.40 |
| 5 | Daryl Porter Jr. | WVU | FR | CB | 4 | 1 | 43 | 0 | 0.25 |
| 6 | TJ Smith | Kansas St | FR | DB | 6 | 2 | 39 | 0 | 0.33 |
| 7 | Charles Woods | WVU | JR | CB | 2 | 1 | 32 | 0 | 0.50 |
| 7 | Ross Elder | Kansas St | SR | DB | 6 | 1 | 32 | 0 | 0.17 |
| 9 | Jacobee Bryant | Kansas | FR | CB | 4 | 2 | 31 | 1 | 0.50 |
| 10 | Gavin Potter | Kansas | JR | LB | 4 | 1 | 28 | 1 | 0.25 |
| 10 | Sean Mahone | WVU | SR | S | 4 | 1 | 28 | 0 | 0.25 |
| 12 | Nick Session | Okla St | FR | S | 2 | 1 | 27 | 0 | 0.50 |
| 13 | Jake Hummel | Iowa State | SR | LB | 5 | 1 | 24 | 1 | 0.20 |
| 14 | Jalen Pitre | Baylor | SR | S | 5 | 2 | 20 | 0 | 0.40 |
| 14 | Kolby Harvell-Peel | Okla St | SR | S | 4 | 1 | 20 | 0 | 0.25 |
| 16 | Tanner McCalister | Okla St | SR | S | 4 | 1 | 13 | 0 | 0.25 |
| 17 | Dadrion Taylor-Demerson | Texas Tech | JR | DB | 5 | 2 | 9 | 0 | 0.40 |
| 18 | Isheem Young | Iowa State | SO | DB | 5 | 1 | 5 | 0 | 0.20 |
| 19 | Christian Holmes | Okla St | SR | CB | 4 | 1 | 2 | 0 | 0.25 |
| 19 | Dee Winters | TCU | JR | LB | 4 | 1 | 2 | 0 | 0.25 |
| 21 | Russ Yeast | Kansas St | SR | DB | 6 | 3 | 1 | 0 | 0.50 |