2021 Big 12 Conference Leaders Interceptions - Games in August/September Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Marquis Waters | Texas Tech | SR | DB | 4 | 1 | 72 | 1 | 0.25 |
| 1 | Josh Thompson | Texas | SR | DB | 4 | 1 | 27 | 1 | 0.25 |
| 1 | JT Woods | Baylor | SR | S | 4 | 1 | 20 | 1 | 0.25 |
| 1 | Riko Jeffers | Texas Tech | SR | LB | 4 | 1 | 13 | 1 | 0.25 |