2025 American Conference Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 12/20/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Army | 1 | 1 | 5 | 6 | 6.00 |
| 1 | Florida Atlantic | 1 | 0 | 6 | 6 | 6.00 |
| 1 | Rice | 1 | 0 | 6 | 6 | 6.00 |
| 4 | Tulane | 4 | 5 | 17 | 22 | 5.50 |
| 5 | North Texas | 1 | 3 | 2 | 5 | 5.00 |
| 6 | Memphis | 2 | 2 | 7 | 9 | 4.50 |
| 6 | Temple | 2 | 1 | 8 | 9 | 4.50 |
| 8 | Tulsa | 2 | 0 | 8 | 8 | 4.00 |
| 8 | UAB | 1 | 1 | 3 | 4 | 4.00 |
| 10 | East Carolina | 2 | 1 | 6 | 7 | 3.50 |
| 11 | USF | 2 | 3 | 2 | 5 | 2.50 |
| 11 | Charlotte | 2 | 1 | 4 | 5 | 2.50 |
| 13 | UTSA | 1 | 0 | 2 | 2 | 2.00 |