2025 American Conference Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 09/13/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Temple | 1 | 1 | 7 | 8 | 8.00 |
| 2 | Tulane | 2 | 5 | 10 | 15 | 7.50 |
| 3 | Army | 1 | 1 | 5 | 6 | 6.00 |
| 3 | Florida Atlantic | 1 | 0 | 6 | 6 | 6.00 |
| 3 | Rice | 1 | 0 | 6 | 6 | 6.00 |
| 6 | North Texas | 1 | 3 | 2 | 5 | 5.00 |
| 7 | East Carolina | 1 | 1 | 3 | 4 | 4.00 |
| 8 | USF | 2 | 3 | 2 | 5 | 2.50 |
| 9 | Charlotte | 1 | 0 | 2 | 2 | 2.00 |
| 9 | UTSA | 1 | 0 | 2 | 2 | 2.00 |