2025 American Conference Leaders Passes Defended - Games on the Road/Neutral Site Only through 11/01/2025
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | East Carolina | 4 | 4 | 16 | 20 | 5.00 |
| 2 | UTSA | 4 | 0 | 17 | 17 | 4.25 |
| 3 | Army | 5 | 6 | 14 | 20 | 4.00 |
| 3 | Memphis | 5 | 4 | 16 | 20 | 4.00 |
| 3 | USF | 4 | 6 | 10 | 16 | 4.00 |
| 6 | Navy | 3 | 1 | 10 | 11 | 3.67 |
| 7 | Rice | 4 | 2 | 12 | 14 | 3.50 |
| 7 | Tulsa | 4 | 2 | 12 | 14 | 3.50 |
| 7 | Tulane | 4 | 1 | 13 | 14 | 3.50 |
| 10 | Temple | 4 | 2 | 11 | 13 | 3.25 |
| 11 | Florida Atlantic | 5 | 0 | 16 | 16 | 3.20 |
| 12 | North Texas | 3 | 1 | 6 | 7 | 2.33 |
| 13 | UAB | 4 | 2 | 6 | 8 | 2.00 |
| 13 | Charlotte | 2 | 2 | 2 | 4 | 2.00 |