2025 Conference USA Leaders Opponent First Downs - Games vs. FBS Power 5 Conference Teams Only through 11/01/2025
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Middle Tennessee State | 1 | 6 | 14 | 1 | 21 | 21.0 |
| 1 | Louisiana Tech | 1 | 6 | 15 | 6 | 27 | 27.0 |
| 3 | Delaware | 1 | 9 | 10 | 2 | 21 | 21.0 |
| 3 | Jacksonville State | 1 | 9 | 12 | 2 | 23 | 23.0 |
| 5 | FIU | 1 | 10 | 9 | 1 | 20 | 20.0 |
| 6 | Sam Houston State | 1 | 13 | 13 | 0 | 26 | 26.0 |
| 7 | UTEP | 1 | 15 | 6 | 2 | 23 | 23.0 |
| 8 | Missouri State | 2 | 17 | 27 | 7 | 51 | 25.5 |
| 9 | Kennesaw State | 2 | 22 | 23 | 3 | 48 | 24.0 |