2021 Conference USA Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UTSA | 1 | 150 | 266 | 78 | 416 | 5.33 | 416.0 |
| 2 | UAB | 1 | 163 | 376 | 60 | 539 | 8.98 | 539.0 |
| 3 | Old Dominion | 1 | 164 | 188 | 70 | 352 | 5.03 | 352.0 |
| 4 | Florida International | 1 | 177 | 407 | 74 | 584 | 7.89 | 584.0 |
| 5 | Southern Mississippi | 1 | 211 | 395 | 59 | 606 | 10.27 | 606.0 |
| 6 | Middle Tennessee | 1 | 224 | 159 | 67 | 383 | 5.72 | 383.0 |
| 7 | Louisiana Tech | 2 | 232 | 621 | 133 | 853 | 6.41 | 426.5 |
| 8 | North Texas | 1 | 306 | 168 | 73 | 474 | 6.49 | 474.0 |
| 9 | Western Kentucky | 2 | 326 | 700 | 165 | 1026 | 6.22 | 513.0 |
| 10 | Florida Atlantic | 1 | 400 | 153 | 81 | 553 | 6.83 | 553.0 |
| 11 | Rice | 2 | 672 | 321 | 127 | 993 | 7.82 | 496.5 |
| 12 | Charlotte | 2 | 689 | 306 | 142 | 995 | 7.01 | 497.5 |