2021 American Athletic Conference Leaders Interceptions - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Ja'Quan McMillian | ECU | SO | CB | 10 | 5 | 42 | 1 | 0.50 |
| 1 | Coby Bryant | Cincinnati | SR | CB | 11 | 3 | 95 | 1 | 0.27 |
| 1 | Antonio Grier | S Florida | SR | LB | 8 | 2 | 69 | 1 | 0.25 |
| 1 | Kevin Henry | Tulane | SR | LB | 8 | 2 | 53 | 1 | 0.25 |
| 1 | Malik Fleming | ECU | SO | CB | 10 | 2 | 31 | 1 | 0.20 |
| 1 | Manny Walker | Temple | SR | DE | 10 | 2 | 11 | 1 | 0.20 |
| 1 | Gervarrius Owens | Houston | JR | S | 12 | 2 | 73 | 1 | 0.17 |
| 1 | Alex Hogan | Houston | JR | CB | 13 | 2 | 91 | 1 | 0.15 |