2021 American Athletic Conference Leaders Interceptions - Games in August/September Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Ja'Quan McMillian | ECU | SO | CB | 4 | 3 | 43 | 1 | 0.75 |
| 1 | Manny Walker | Temple | SR | DE | 4 | 2 | 11 | 1 | 0.50 |
| 1 | Justin Wright | Tulsa | JR | LB | 3 | 1 | 55 | 1 | 0.33 |
| 1 | Alex Hogan | Houston | JR | CB | 4 | 1 | 91 | 1 | 0.25 |
| 1 | Kevin Henry | Tulane | SR | LB | 4 | 1 | 49 | 1 | 0.25 |