2021 American Athletic Conference Leaders Interceptions - Games Won Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Ja'Quan McMillian | ECU | SO | CB | 7 | 4 | 22 | 1 | 0.57 |
| 1 | Coby Bryant | Cincinnati | SR | CB | 13 | 3 | 95 | 1 | 0.23 |
| 1 | Manny Walker | Temple | SR | DE | 3 | 2 | 11 | 1 | 0.67 |
| 1 | Malik Fleming | ECU | SO | CB | 7 | 2 | 31 | 1 | 0.29 |
| 1 | Gervarrius Owens | Houston | JR | S | 11 | 2 | 73 | 1 | 0.18 |
| 1 | Alex Hogan | Houston | JR | CB | 12 | 2 | 91 | 1 | 0.17 |
| 1 | Kevin Henry | Tulane | SR | LB | 2 | 1 | 49 | 1 | 0.50 |