2021 American Athletic Conference Leaders Interceptions - Games at Home Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Antonio Grier | S Florida | SR | LB | 6 | 2 | 69 | 1 | 0.33 |
| 1 | Kevin Henry | Tulane | SR | LB | 6 | 2 | 53 | 1 | 0.33 |
| 1 | Ja'Quan McMillian | ECU | SO | CB | 6 | 2 | 20 | 1 | 0.33 |
| 1 | Coby Bryant | Cincinnati | SR | CB | 7 | 2 | 95 | 1 | 0.29 |
| 1 | Malik Fleming | ECU | SO | CB | 6 | 1 | 31 | 1 | 0.17 |