2021 American Athletic Conference Leaders Interceptions - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Ja'Quan McMillian | ECU | SO | CB | 10 | 5 | 42 | 1 | 0.50 |
| 1 | Marcus Jones | Houston | SR | CB | 12 | 5 | 2 | 0 | 0.42 |
| 3 | TieNeal Martin | Tulsa | SR | S | 8 | 3 | 0 | 0 | 0.38 |
| 3 | Arquon Bush | Cincinnati | JR | CB | 10 | 3 | 7 | 0 | 0.30 |
| 3 | Coby Bryant | Cincinnati | SR | CB | 11 | 3 | 95 | 1 | 0.27 |
| 3 | Deshawn Pace | Cincinnati | SO | LB | 11 | 3 | 51 | 0 | 0.27 |
| 7 | Mekhi LaPointe | S Florida | SR | DB | 7 | 2 | 50 | 0 | 0.29 |
| 7 | Isaiah Nwokobia | SMU | FR | S | 7 | 2 | 19 | 0 | 0.29 |
| 7 | Antonio Grier | S Florida | SR | LB | 8 | 2 | 69 | 1 | 0.25 |
| 7 | Kevin Henry | Tulane | SR | LB | 8 | 2 | 53 | 1 | 0.25 |
| 7 | Macon Clark | Tulane | JR | S | 8 | 2 | 45 | 0 | 0.25 |
| 7 | Dwayne Boyles | S Florida | SR | LB | 8 | 2 | 4 | 0 | 0.25 |
| 7 | Travon Fuller | Tulsa | SR | CB | 9 | 2 | 60 | 0 | 0.22 |
| 7 | Jalen Ware | Temple | JR | SAF | 9 | 2 | 20 | 0 | 0.22 |
| 7 | Malik Fleming | ECU | SO | CB | 10 | 2 | 31 | 1 | 0.20 |
| 7 | Warren Saba | ECU | SR | SAF | 10 | 2 | 31 | 0 | 0.20 |
| 7 | Isaac Slade-Matautia | SMU | JR | LB | 10 | 2 | 27 | 0 | 0.20 |
| 7 | Trevor Denbow | SMU | SR | S | 10 | 2 | 18 | 0 | 0.20 |
| 7 | Manny Walker | Temple | SR | DE | 10 | 2 | 11 | 1 | 0.20 |
| 7 | Dyllon Lester | UCF | JR | DB | 11 | 2 | 34 | 0 | 0.18 |
| 7 | Tatum Bethune | UCF | JR | LB | 11 | 2 | 23 | 0 | 0.18 |
| 7 | Ja'von Hicks | Cincinnati | SR | S | 11 | 2 | 18 | 0 | 0.18 |
| 7 | Ahmad Gardner | Cincinnati | JR | CB | 11 | 2 | 3 | 0 | 0.18 |
| 7 | Jacobi Francis | Memphis | SR | DB | 11 | 2 | 1 | 0 | 0.18 |
| 7 | Gervarrius Owens | Houston | JR | S | 12 | 2 | 73 | 1 | 0.17 |
| 7 | Gleson Sprewell | Houston | SR | S | 12 | 2 | 44 | 0 | 0.17 |
| 7 | Divaad Wilson | UCF | JR | DB | 12 | 2 | 25 | 0 | 0.17 |
| 7 | Alex Hogan | Houston | JR | CB | 13 | 2 | 91 | 1 | 0.15 |
| 29 | Kevin Brennan | Navy | SR | FS | 4 | 1 | 15 | 0 | 0.25 |
| 29 | Christian Williams | S Florida | SO | S | 5 | 1 | 0 | 0 | 0.20 |
| 29 | Brock Nichols | S Florida | SR | S | 6 | 1 | 38 | 0 | 0.17 |
| 29 | Lance Robinson | Tulane | SO | DB | 6 | 1 | 13 | 0 | 0.17 |
| 29 | Johnny Hodges | Navy | JR | LB | 6 | 1 | 0 | 0 | 0.17 |
| 29 | Juan Powell | ECU | FR | SAF | 7 | 1 | 4 | 0 | 0.14 |
| 29 | Derrion Rakestraw | Tulane | SR | S | 8 | 1 | 12 | 0 | 0.13 |
| 29 | Mbiti Williams Jr. | Navy | FR | CB | 8 | 1 | 7 | 0 | 0.13 |
| 29 | Jadon Canady | Tulane | FR | DB | 8 | 1 | 0 | 0 | 0.13 |
| 29 | Taylor Robinson | Navy | JR | BAN | 8 | 1 | 0 | 0 | 0.13 |
| 29 | Justin Hodges | UCF | SO | DB | 9 | 1 | 0 | 0 | 0.11 |
| 29 | Keyshawn Paul | Temple | JR | CB | 9 | 1 | 0 | 0 | 0.11 |
| 29 | LJ Wallace | Tulsa | JR | S | 9 | 1 | 0 | 0 | 0.11 |
| 29 | Bryson Powers | Tulsa | SR | S | 9 | 1 | 0 | 0 | 0.11 |
| 29 | Diego Fagot | Navy | SR | LB | 9 | 1 | 0 | 0 | 0.11 |
| 29 | Rayuan Lane | Navy | FR | S | 9 | 1 | 0 | 0 | 0.11 |
| 29 | Bryan Massey | SMU | SO | S | 10 | 1 | 48 | 0 | 0.10 |
| 29 | Shawn Dourseau | ECU | SO | SAF | 10 | 1 | 33 | 0 | 0.10 |
| 29 | Freddie Johnson | Temple | SR | CB | 10 | 1 | 25 | 0 | 0.10 |
| 29 | Delano Robinson | SMU | SR | LB | 10 | 1 | 8 | 0 | 0.10 |
| 29 | Teagan Wilk | ECU | FR | SAF | 10 | 1 | 6 | 0 | 0.10 |
| 29 | Tre'mon Morris-Brash | UCF | JR | DL | 10 | 1 | 0 | 0 | 0.10 |